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2025 :

86. Concise Enantioselective Total Syntheses of Rearranged ent-Trachylobane Diterpenoids (–)-Wallichanols A and B Dattatraya H. Dethe, Nitin Sharma, Sakshi Juyal Angew. Chem., Int. Ed. 2025, e202505766.

https://doi.org/10.1002/anie.202505766

85. Biomimetic syntheses of kadcoccitane H and kadcotrione C methyl ester Dattatraya H. Dethe, Salman A. Siddiqui, Chirantan Singha Chem. Sci. 2025, 10.1039.D5SC00669D. https://doi.org/10.1039/D5SC00669D.

This article is part of the themed collection: 2025 Chemical Science HOT Article Collection

84. Biomimetic Synthesis of Cucurbalsaminone A Dattatraya H. Dethe, Chirantan Singha, Salman A. Siddiqui Org. Lett. 2025 (just accepted), https://doi.org/10.1021/acs.orglett.5c00440

ChemRxiv: November, 2024, https://doi.org/10.26434/chemrxiv-2024-gw8l0

2024 :

83. Ru(II)-Catalyzed C–H Activation/[4+2] Annulation of Sulfoxonium Ylide with Maleimide: Access to Fused Benzo[e]isoindole-1,3,5-trione Dattatraya H. Dethe, Vimlesh Kumar, Rahul Das Org. Lett. 2024, 26, 32, 6830–6834.

82. Ruthenium-Catalysed Interrupted Transfer Hydrogenation: A Highly Efficient Approach for Reductive Functionalization of Quinolinium and Napthyridinium Salts Dattatraya H. Dethe, Prabhakar Singh, Asha joshi, Proshanta Biswas J. Org. Chem. 2024, 89, 18, 13167–13178.

81. Ru(II)-Catalyzed C-H Alkylation of N-Benzyltriflamides with Maleimides: Synthesis of o-Succinimide substituted Benzaldehydes Dattatraya H. Dethe, Vimlesh Kumar, Arnadeep data Chem. Eur. J. 2024, 30, e202401301

80. Total synthesis of Diplofuranone A and Diapolic acid Dattatraya H. Dethe, Vimlesh Kumar, Nagabhushana C. Beeralingappa Org. Biomol. Chem., 2024, 22, 3589-3591

79. Enantioselective Total Synthesis of Atisane Diterpenoids: (+)-Sapinsigins H, (+)-Agallochaol C, and (+)-16α, 17-dihydroxy-atisan-3-one Dattatraya H. Dethe, Nitin Sharma, Sakshi Juyal, Prabhakar Singh, Salman A. Siddiqui Chem. Comm. 2024, 60, 7866-7869.

Featured on the front cover of the Chem. Commun. (PDF)

78. Asymmetric Total Synthesis of (+)-Verrubenzospirolactone and (+)-Capillobenzopyranol Dattatraya H. Dethe, Sakshi Juyal, Nitin Sharma, Utpal Kundu Org. Lett. 2024, 26, 15, 3010–3013.

Highlighted in Synfacts by Prof Erick M. Carreira et al.

Synthesis of (+)-Verrubenzospirolactone

Synfacts 2024; 20(08): 0787 (DOI: 10.1055/s-0043-1773331)

77. Ru(II)-Catalyzed Deoxygenative Formal [3 + 1 + 2] Benzannulation of Allyl Alcohols and Acetylenediesters via C−H Activation and Selective Carbon−Carbon Triple Bond Cleavage Dattatraya H. Dethe, Amar Uike and Nagabhushana C. Beeralingappa Org. Lett. 2024, 26, 10, 2013–2017

2023 :

76. Palladium Catalyzed Asymmetric Desymmetrization Approach to Enantioenriched 1,3- disubstituted Isoindolines Dattatraya H. Dethe*, Vimlesh Kumar and Manmohan Shukla Chem. Sci., 2023, 14, 11267-11272.

75. Rheological investigation of the network structure in mixed gels of Kappa and Iota Carrageenan Tulika Bhattacharyya, Chandra S. Palla, Dattatraya H. Dethe, Yogesh M. Joshi Food Hydrocolloids, 2024, 146, 109298.

DOI: https://doi.org/10.1016/j.foodhyd.2023.109298

2022 :

74. Dethe, D. H.;* Nagabhushana, C. B.; Singha, C. Rhodium-Catalyzed Enantioselective C-H Functionalization using Chiral Cp Ligands. Wiley: Handbook of CH-Functionalization (CHF) article CHF-0029.

73. Dethe, D. H.;* Nagabhushana, C. B.; Koley, S. Natural Product Synthesis by Rhodium and Ruthenium Catalyzed C-H Activation. Wiley: Handbook of CH-Functionalization (CHF) article CHF-0090.

72. Diversification of (E,E)-1,6-Dioxo-2,4-dienes for the Synthesis of (+)-Aspicillin, Isolaurepan and β-Parinaric acid Dattatraya H. Dethe*, Aparna Srivastava†, Appasaheb K. Nirpal†, Nagabhushana C. B., Vimlesh Kumar, Arsheed A. Bhat. J. Org. Chem. 2022, 87, 16, 11021–11030

71. Bioinspired Enantioselective Total Syntheses of Antibacterial Cal-listrilones Enabled by Double SN2′ Cascade. Dattatraya H. Dethe,* Balu D. Dherange,‡ Saikat Das‡ and Aparna Srivastava Chem. Comm. 2022, 58, 36, 5474-5477

70. Synthesis of Polyene Bioactive Natural Products: FR252921 and Vitamin A. Dattatraya H. Dethe*, Vimlesh Kumar†, Nagabhushana C. B.†, Kunj B. Mishra, Appasaheb K. Nirpal. Org. Lett. 2022, 24, 11, 2203–2207

69. Ruthenium Catalyzed Stereo- and Chemoselective Oxidative Coupling of Vinyl Ketones: An Efficient Access to (E, E)-1,6-dioxo-2,4-dienes Dattatraya H. Dethe,* Appasaheb K. Nirpal†, Nagabhushana C. B.†, Vimlesh Kumar†, Aparna Srivastava, Kunj B. Mishra, Arsheed A. Bhat Chem. Commun., 2022, 58, 3063-3066.

68. Asymmetric Ru/Cinchonine Dual Catalysis for the One-Pot Synthesis of Optically Active Phthalides from Benzoic acids and Acrylates Dattatraya H. Dethe*, Nagabhushana C. B.†, Salman A. Siddiqui†, and Prakash N. Chavan J. Org. Chem. 2022, 87, 7, 4617–4630

2021 :

67. Enantioselective First Total Syntheses of Antiviral Xiamycins D and E, Dattatraya H. Dethe,* and Manmohan Shukla, Chem. Commun., 2021, 57, 10644-10646.

66. Carboxylic Acid Promoted, Redox-Neutral Ru-Catalyzed C-H Allylation of Aromatic Ketones, Dattatraya H. Dethe*, Nagabhushana C. B. and Dherange B., Eur. J. Org. Chem. 2021, 2021, 4611.

65. A new dibenzofuran derivative from the stem bark of with anti-inflammatory and cytotoxic activities., Dattatraya H. Dethe,* FeuyaTchouya G. R., Nat. Prod. Res., 2021, 36:6, 1503-1514.

64. Weakly Coordinating, Hydroxyl Directed Ruthenium Catalyzed C−H Alkylation of Ubiquitous Benzyl Alcohols with Maleimides., Dattatraya H. Dethe,* Nagabhushana C. B., and Vimlesh Kumar, Org. Lett., 2021, 23, 6267

63. Ruthenium Catalyzed Oxidative Cross-Coupling Reaction of Activated Olefins With Vinyl Boronates for the Synthesis of (E,E)-1,3-Dienes. Dattatraya H. Dethe* Nagabhushana C. B., and Uike Amar J. Org. Chem., 2021, 86, 3444.

62. Enantiospecific Total Synthesis of (−)-Japonicol C, Dattatraya H. Dethe,* Appasaheb K. Nirpal, Org. Lett., 2021, 23, 2648.

61. Ruthenium catalyzed formal sp3 C–H activation of allylsilanes/esters with olefins efficient access to functionalized 1,3-dienes, Dattatraya H. Dethe*, Nagabhushana C. B., Das S., Appasaheb K. Nirpal, Chem. Sci., 2021, 12, 4367

2020 :

60. Sc(OTf)3‐Catalyzed Synthesis of Symmetrical Dithioacetals and Bisarylmethanes Using Nitromethane as a Methylene Source, Dattatraya H. Dethe,* Manmohan Shukla, and Balu D. Dherange, Org. Lett., 2020, 22, 5778.

59. Ruthenium-Catalyzed Direct Dehydrogenative Cross-Coupling of Allyl Alcohols and Acrylates: Application to Total Synthesis of Hydroxy β-Sanshool, ZP-Amide I, and Chondrillin, Dattatraya H. Dethe*, Nagabhusan C. B., Org. Lett., 2020, 22, 1618.

58. Cp*Co(III)-Catalyzed Ketone-Directed ortho-C–H Activation for the Synthesis of Indene Derivatives, Dattatraya H. Dethe*, Nagabhushana C. B., and Bhat Arsheed A., J. Org. Chem. 2020, 85, 7565

2019 :

57. Total Synthesis of (-)-Phomoarcherin, Dattatraya H. Dethe*, B Vijay Kumar, J. Org. Chem. 2019, 84, 14053

56. Bio-Inspired Enantioselective Total Syntheses of (−)-Viminalins A, B, H, I, N and Structural Reassignment of (−)-Viminalin M, Dattatraya H. Dethe*, Appasaheb K. Nirpal, Org. Biomol. Chem. 2019, 16, 7507

55. Enantioselective Total Synthesis of (-)-Strongylophorines-2 and 9 Dethe*, Dattatraya H.; Sau, Susanta Kumar, Org. Lett., 2019, 21, 3799

2018 :

54. Biomimetic Enantioselective Total Synthesis of (-)-Petromindole Dethe*, Dattatraya H.; Sau, Susanta Kumar, Org. Lett., 2018, 20, 632.

53. Rapid One‐Pot Access to Unique 3,4‐Dihydrothiopyrano[3,4‐b]indol‐1(9H)‐ imines via Bi(OTf)3‐Catalysed Tandem Friedel–Crafts Alkylation/Thia‐Michael Addition, Dethe*, Dattatraya H.; Kumar, Vijay B., and Mandal, A., Eur. J. Org. Chem., 2018, 5417

52. Biomimetic Total Syntheses of Callistrilones A, B, and D Dethe*, Dattatraya H.; Dherange, Balu D.; Das, Saikat, Org. Lett., 2018, 20, 680.

51. Enantioselective Total Synthesis and Assignment of the Absolute Configuration of the Meroterpenoid (+)-Taondiol Dattatraya H. Dethe*, Mahapatra, Samarpita; Sau, Susant Kumar, Org. Lett., 2018, 20, 2766.

50. Enantiospecific Total Syntheses of (+)-Hapalindole H and (-)-12-epi-Hapalindole U Dattatraya H. Dethe*, Das, Saikat; Kumar, Vijay B., Chem. Eur. J., 2018, 24, 8980.

49. Total Synthesis of Adunctin B Dattatraya H. Dethe*, Dherange, Balu D., J. Org. Chem. 2018, 83, 3392.

48. Biomimetic total syntheses of chromane meroterpenoids, guadials B and C, guapsidial A and psiguajadial D, Dattatraya H. Dethe*, Kumar, Vijay B.; Maiti, Rakesh, Org. Biomol. Chem., 2018, 16, 4793

47. Structural and spectroscopic analysis of indole alkaloids: Molecular docking and DFT approach Singh, Harshita; Singh, Swapnil; Agarwal, Parag, Dattatraya H. Dethe*, J. Mol. Str., 2018, 1153, 262.

46. Unsymmetrical Disulfide Synthesis through Photoredox Catalysis, Dattatraya H. Dethe*, Aparna Srivastava, Balu D. Dherange, B. Vijay Kumar, Adv. Synth Cat., 2018, 360, 3020.

45. Synthetic Studies toward the Natural Product Tripartin, the FirstNatural Histone Lysine Demethylase Inhibitor Dattatraya H. Detheand Raghavender Boda, ACS Omega, 2018, 3, 9303−9309.

2017 :

44. Conformational Study and Vibrational Spectroscopic (FT-IR and FT-Raman) Analysis of an Alkaloid-Borreverine Derivative Singh, Swapnil; Singh, Harshita; Karthick, T.; Tandon, P. Dethe, D. H., Erande, R. D. Anal. Sci, 2017, 33, 99.

43. Enantiospecific total syntheses of meroterpenoids (−)-F1839-I and (−)-corallidictyals B and D, Dattatraya H. Dethe*; Balu D. Dherange, Saghir Ali and Mahesh M. Parsutkar, Org. Biomol. Chem., 2017, 15, 65.

42. Enantiospecific syntheses of hongoquercin A, B and chromazonarol; Dattatraya H. Dethe*, Ganesh M. Murhade, Balu D. Dherange, Susanta Kumar Sau, Eur. J. Org. Chem., 2017, 1143.

41. Thiol-Yne Coupling of Propargylamine under Solvent-Free Conditions by Bond Anion Relay Chemistry: An Efficient Synthesis of Thiazolidin-2-ylideneamine Ranjan, Alok; Deore, Abhijit S.; Yerande, Swapnil G. Dethe*, D. H., Eur. J. Org. Chem., 2017, 4130.

2016 :

40. A Novel Pd-catalyzed Annulation Reaction for the Syntheses of Pyrroloindoles and Pyrroloquinolines, Dattatraya H. Dethe* and Raghavender Boda, Chem. Eur. J., 2016, 22, 106.

39. Combine experimental and theoretical investigation on an alkaloid– Dimethylisoborreverine, Swapnil Singh, Harshita Singh, T. Karthick, Parag Agarwal, Rohan D. Erande, Dattatraya H. Dethe*, Poonam Tandon*, J. Mol. Str., 2016, 1103, 187.

38. Expedient Synthesis of Densely Substituted Pyrrolo[1,2-a]indoles. Dattatraya H. Dethe٭, R. Boda., Org. Biomol. Chem., 2016, 14, 5843.

37. Conformational study and vibrational spectroscopic (FT-IR and FT-Raman) analysis of an alkaloid-Borreverine derivative; Swapnil Singh, Harshita Singh, T. Karthick, Poonam Tandon, Dattatraya Dethe* and Rohan D. Erande, J. Mol. Str, 2016, 1103, 187.

36. Biomimetic Enantioselective Total Synthesis of (−)-Mycoleptodiscin A, Dattatraya H. Dethe;* Susanta Kumar Sau, and Samarpita Mahapatra, Org. Lett., 2016, 18, 6392.

2015 :

35. Hg(OAc)2 mediated highly regio- and diastereoselective allylic tert-acetylation of olefins, Dattatraya H. Dethe*, Balu D. Dherange and Raghavender Boda, Org. Chem. Front., 2015, 2, 159.

34. Protecting group free enantiospecific total syntheses of structurally diverse natural products of the tetrahydrocannabinoid family, Dattatraya H. Dethe,* Rohan D. Erande, Samarpita Mahapatra, Saikat Das and Vijay Kumar B, Chem. Commun., 2015, 51, 2871.

33. Lewis acid catalyzed Nazarov type cyclization for the synthesis of substituted indane framework: total synthesis of (±)-mutisianthol, Dattatraya H. Dethe,* Raghavender Boda and Ganesh M. Murhade, Org. Chem. Front., 2015, 2, 645.

32. Enantiospecific total syntheses and assignment of absolute configuration of cannabinol- skeletal carbazole alkaloids murrayamines-O and -P, Dattatraya H. Dethe,* Saikat Das, Balu D. Dherange and Samarpita Mahapatra, Chem. Eur. J., 2015, 21, 8347.

31. Concise Asymmetric Total Synthesis of Bruceolline J, Dattatraya H. Dethe,* and B. Vijay Kumar, Org. Chem. Front., 2015, 2, 548.

30. One Pot Synthesis of 2-Amino-1,3-Selenazole through Intermediary Amidinoselenourea, Alok Ranjan, Ragini Yerande, Mahantesh Jadhav, Swapnil G. Yerande* and Dattatraya H. Dethe*, Eur. J. Org. Chem., 2015, 3230.

29. Enantioselective Total Syntheses of (+)-Hostmanin A, (−)-Linderol A, (+)-Methyllinderatin and Structural Reassignment of Adunctin E, Dattatraya H. Dethe,* and Balu D. Dherange., J. Org. Chem., 2015, 80, 4526.

28. FeCl3 mediated Synthesis of Substituted Indenones by Formal [2+2] Cycloaddition/Ring Opening Cascade of O-Keto-Cinnamates, Dattatraya H. Dethe* and Ganesh M. Murhade, Chem. Commun.,2015, 51, 10891.

27. FeCl3.6H2O catalyzed intramolecular olefin-Michael cyclization reaction of styrenes for the synthesis of indene: Application in total synthesis of (±) Jungianol, Dattatraya H. Dethe* and Ganesh Murhade, J. Org. Chem., 2015, 80, 8367.

26. Asymmetric Alkynylation/Hydrothiolation Cascade: Enantioselective Synthesis of Thiazolidine-2-imines from Imine, Acetylene and Isothiocyanate, Alok Ranjan, Anupam Mandal, Swapnil G. Yerande, Dattatraya H. Dethe*, Chem. Commun., 2015, 51, 14215.

25. Femtosecond Dynamics of Photoinducedcis-trans Isomerisation of Ethyl-3-(1H-indole-3-yl) acrylate, Bhaswati Sengupta, Puspal Mukherjee, Saikat Das, Shahnawaz Rafiq, Shradhey Gupta, Dattatraya H. Dethe*, and Pratik Sen,* Chem. Phys. Lett. 2015, 31, 638.

24. A glowing antioxidant from Tasar silk cocoon, T. S. Kusurkar, , K. Bhargava, S. Khurana, N. K., Dattatraya H. Dethe and M. Das, RSC Adv., 2015, 5, 104563.

2014 :

23. Enantioselective total syntheses and determination of absolute configuration of marine toxins, oxazinins. Dattatraya H. Dethe,* and Alok Ranjan., RSC Advances, 2014, 3, 23692.

22. Remarkable Switch of Regioselectivity in Diels–Alder Reaction: Divergent Total Synthesis of Borreverine, Caulindoles, and Flinderoles, Dattatraya H. Dethe,* Rohan D. Erande, and Balu D. Dherange., Org. Lett., 2014, 16, 2764.

21. Diversity-Oriented Synthesis of Calothrixins and Ellipticines. Dattatraya H. Dethe,* and Ganesh M. Murhade., Eur. J. Org. Chem., 2014, 31, 6953.

20. Base-Mediated Hydroamination of Propargylamine: A Regioselective Intramolecular 5- exo-dig Cycloisomerization en Route to Imidazole-2-thione, Alok Ranjan, Ragini Yerande, Prasad B. Wakchaure, Swapnil G. Yerande and Dattatraya H. Dethe*, Org. Lett., 2014, 16, 5788.

2013 :

19. FeCl3 Catalyzed Prins-Type Cyclization for the Synthesis of Highly Substituted Indenes: Application to the Total Synthesis of (±)-Jungianol and epi-Jungianol. Dattatraya H. Dethe* and Ganesh Murhade., Org. Lett., 2013, 15, 429.

18. Cu(OTf)2 catalysed [6+2] cycloaddition reaction for the synthesis of highly substituted pyrrolo[1,2-a]indoles: rapid construction of yuremamine core. Dattatraya H. Dethe*, Raghavender Boda and Saikat Das, Chem. Comm., 2013, 49, 3260.

17. Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl) benzamide inhibitors of glycine transporter-1. Christopher L. Cioffi, Dethe Dattatraya H., Bioorg. Med. Chem. Lett.,2013, 23, 1257.

16. FeCl3 mediated intramolecular olefin-cation cyclisation of cinnamates for the synthesis of highly substituted indenes. Dattatraya H. Dethe* and Ganesh Murhade, Chem. Comm., 2013, 8051.

15. Biomimetic total syntheses of borreverine and flinderole alkaloids. Dattatraya H. Dethe,* Rohan D Erande, and Alok Ranjan., J. Org. Chem., 2013, 78, 10106.

2011 :

14. Asymmetric first total syntheses and assignment of absolute configuration of oxazinin-5, oxazinin-6 and preoxazinin-7. Dattatraya H. Dethe٭, Alok Ranjan and Vijendra Pardeshi., Org. Biomol. Chem., 2011, 9, 7990.

13. Biomimetic total syntheses of flinderoles B and C., Dattatraya H. Dethe٭, Rohan Erande, and Alok Ranjan., J. Am. Chem. Soc., 2011, 133, 2864.

From Abroad (Postdoctoral work)

12. Chemical Synthesis and Biological Evaluation of Palmerolide A Analogues, K. C. Nicolaou, Leung Yiu Chung, Dethe Dattatraya H., Guduru Ramakrishna, Sun Yaping, Jessie Lim, Chen David., J. Am. Chem. Soc., 2008, 130, 10019

11. Total Syntheses of Amythiamicins A, B and C., K. C. Nicolaou, Dethe Dattatraya H., Chen David., Chem. Comm., 2008, 2632.

10. Total Synthesis of Thiopeptide Antibiotics GE2270A, GE2270C1 and GE2270T, K. C. Nicolaou, Dethe Dattatraya H., Leung Yiu Chung, Bin Zou, Chen David., Chemistry: An Asian Journal, 2008, 3, 413.

09. Total Synthesis of Antibiotics GE2270A and GE2270T, K. C. Nicolaou, Bin Zou, Dethe Dattatraya H., Li Dongbo, Chen David, Angew. Chem. Int. Ed., 2006, 45, 7786.

From India (PhD work)

08. Enantiospecific synthesis of pacifigorgianes Srikrishna, A.; Dethe, Dattatraya H., Indian J. Chem. 2005, 51, 345.

07. Enantiospecific first total synthesis of cucumin-H Srikrishna, A.; Dattatraya H. Dethe, Indian J. Chem. 2005, 50, 1092.

06. An efficient construction of a C3-symmetric macrocycle by head to tail cyclotrimerization of an unsymmtetricaldiene via a sequence of highly region- and stereoselective metathesis reactions, A. Srikrishna and Dattatraya H. Dethe, Tetrahedron Lett., 2005, 46, 3381.

2004 :

05. Synthetic approaches to gunacastepenes. Enantiospecific synthesis of BC and AB ring systems of guanacatepenes and rameswaralide, A. Srikrishna and Dattatraya H. Dethe, Org. Lett. 2004, 6, 165.

04. Enantiospecific construction of BC-ring system of taxanes, A. Srikrishna, Dattatraya H. Dethe and P. R. Kumar; Tetrahedron Lett., 2004, 45, 2939.

2003 :

03. Enantiospecific first total synthesis and assignment of absolute configuration of the sesquiterpene (-)-Cucumin-H, A. Srikrishna and Dattatraya H. Dethe, Org. Lett. 2003, 5, 2295.

02. A convenient enantiospecific methodology for (-)-(1R,5S)-1,5- dimethylbicyclo[3.3.0]octa-2,7-dione: A formal total synthesis of (-)-ceratopicanol, A.Srikrishna, N. C. babu and Dattatraya H. Dethe, Indian J. Chem. 2003, 42B, 1688.

01. An efficient ring closing metathesis reaction of the geminallydisubstituted olefins using first generation Grubb’s catalyst: enatiospecific synthesis of pacifiogorgianes, A Srikrishna and Dattatraya H. Dethe, Tetrahedron Lett. 2003, 43, 1109.

Patent:

Flinderole analogues and process for synthesis thereof., Dethe Dattatraya H., Erande Rohan D., Ranjan Alok, PCT Int. Appl., 2012, WO 2012107934 A1 20120816

DD RESEARCH GROUP

Indian Institute of Technology Kanpur