The research in our group focus on the development of new synthetic methods and strategies, and their application in the total synthesis of natural products and biologically important compounds. A major thrust of our current research is the design and invention of new annulation strategies for the synthesis of carbocyclic and heterocyclic systems. Our research program is focused on the development of new reagents and methods for organic synthesis, with an emphasis on asymmetric catalysis. The achievement of our objectives requires an understanding of stereoselective synthesis, physical organic chemistry, and metal-based reactivity.